This seminar will cover a risk-based approach to a cleaning and disinfection program and new recent case studies in contamination control. Details will be provided on how to follow a risk-based approach for cleaning and disinfection, and microbial identification, using good science. The most common causes of contamination will be conveyed in case studies with fungal spore, bacterial spore, and Deinococcus contamination. Accurate identification of microorganisms is an important part of tracking and trending a facility’s microbiota and can aide during investigations related to contamination events. There are varied levels of operational needs in the industry and these needs dictate different approaches to microbial identification. The limitations and strengths of the different technologies must be understood in order to choose the most appropriate method for the desired application. Different case studies for microbial identification will be presented, as will solutions on how to proactively prevent contamination from reoccurring.