PDA EU00171 Optimize Your Freeze-drying Process

Ask a Question Exhibitor Standard Contract Clause
A successfully optimized freeze-drying cycle will provide reliable, safe processing in an efficient manner. Each stage of the process – freezing, primary drying and secondary drying – poses its own challenges. Many factors influence the design of the cycle, including the specific thermal characteristics of the product, the type and amount of product per batch or container, and the capabilities of the processing equipment to be used.  

This training course provides an overview of how to develop an optimized freeze-drying process. It will go through each critical stage required to optimize a cycle including: an overview of the freeze drying process, formulation design of freeze dried products, characterization of the formulation in the frozen state prior to freeze drying, cycle development and scale up for freeze drying process (including the iterative approach and also the use of “new” SMART software), and the use of PAT (Process Analytical Technology) for monitoring the process.   
  • Gain a basic understanding of the freeze-drying process, together with the factors that influence the product and process. 
  • Characterization to determine a product critical temperature prior to freeze-drying. 
  • Review formulation development to gain understanding of typical excipients and their purpose in a formulation. 
  • Learn about typical CQAs in freeze dried products, what factors influence these attributes, and methods of monitoring and controlling attributes.  
  • Learn how to develop a freeze-drying process using the traditional iterative (stepwise) approach and how this compares to the use of SMART software. 
  • Gain a basic understanding of typical Process Analytical Technology (PAT) to monitor the freeze-drying process and when primary drying is complete. 


Standard Registration

Member Price


GovernmentMember Only


Health AuthorityMember Only


Early Career ProfessionalMember Only


StudentMember Only


AcademicMember Only




See Qualifying Criteria for Member Types.


WAYS TO REGISTER: 1. Online Registration   2. [email protected]

PDA MEMBERS: Please remember to log in before registering If you come from a Governmental or Health Authority Institution or from an Academic Organization, please contact [email protected] before registering.

If you need to apply for a visa to enter the event country, PDA Europe must be informed of this fact at least 4 weeks before the start of the event.

Day 1

Monday, 13 September 2021

14:00 CEST
Welcome, Opening Remarks and Introductions 

Overview of the Freeze-Drying Process


Freeze Dried Formulations and Typical Use of Common Excipients


Frozen State Characterization


15:45 CEST
Comfort Break

Overview of Typical Process Analytical Technology used in Monitoring Primary Drying


Cycle Development and Scale up: Use of the Iterative Approach and Use of SMART Software


Round-up Discussion and Questions


17:30 CEST
End of Course

Agenda is subject to change.

PLEASE READ  PDA is not affiliated or contracted with any outside hotel contracting company. If someone other than PDA or the PDA chosen hotel contacts you suggesting that they represent any PDA event, they do not. It is PDA's recommendation that you book your hotel directly through the official PDA chosen hotel that is listed on our web site.