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2023 PDA_Training-1988x680

PDA EU00135 Best Practices for Glass Primary Containers

Apr 12 - Apr 13, 2023
Mainz, Germany

  • Education
  • Europe

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Program Highlights

This course will include a Site Visit at the SCHOTT facilities on the 12 April 2023!

This two-day course will offer insights into the science of glass and its inherent properties. It will review container design and dimensioning, cover glass strength and fracture mechanics as well as review the fundamental principles of good glass handling and inspection.


Glass vials, ampoules, syringes and cartridges are commonly used in packaging of parenteral pharmaceuticals. Good glass handling practices are essential to assuring glass-based container performance as intended in maintaining the safety and efficacy of the drug product.

The two-day course will offer insights into the science of glass and its inherent properties. It will review container design and dimensioning, cover glass strength and fracture mechanics as well as review the fundamental principles of good glass handling and inspection. The course will follow step-by-step the processes for packaging of parenterals in vials, ampoules, cartridges and syringes. Further insights into glass breakage including an overview of fracture analysis using fractography will be presented.


  • Technical aptitude
  • Some familiarity with pharmaceutical fill/finish processes


  • Day 1
  • Day 2
  • Wednesday, 12 April 2023

    Welcome and Introduction
    Participants' Expectations

    Manufacture and Characteristics of Glass as Primary Packaging Material

    Glass Science

    • Chemical structure
    • Physical properties
    • Different glass types in the pharmaceutical industry

    Coffee Break

    Glass Making

    • Glass Melting
    • Tubing Production
    • Container conversion
    • Molded containers

    Lunch Break

    Glass Strength and Fracture Mechanics

    • Trigger for glass breakage
    • Crack formation and propagation
    • Theory of Fractography

    Site Visit SCHOTT Tubular Glass Manufacturing

    Coffee Break

    Receiving Inspection of Glass Primary Packaging Material

    Requirements from Pharmacopoeias (EP, JP, USP) and Incoming Inspection

    • Overview Pharmacopoeia
    • Testing Parameters
    • Testing Methods, Equipment, Tools
    • Defects and PDA Technical Report #43

    How to Do in Practice

    • Sampling (AQL)
    • Sample size
    • Testing
    • Documentation
    • Supplier certification & test reduction

    End of Training Course Day 1
  • Thursday, 13 April 2023

    Recap of Learning Objectives Day 1

    Receiving Inspection of Glass Primary Packaging Material (cont.)

    What to Consider, What are the Common Problems, How to Avoid Them

    • Indications for (later) glass breakage | Practical examples

    Coffee Break

    Coordination Process Packaging Manufacturer and Customer

    • Important parameters | Measured variables | Regulating variables | Control loop |Interaction with manufacturer | Effort reduction

    Machine Use of Glass Primary Packaging Material

    Machine Runability of Glass Primary Packaging Material

    • Roughness of glass primary packaging material | Geometrics, tolerances | Quality of glass | Impact of machine speed

    Lunch Break

    Use of Glass Primary Packaging Material Along the Process Chain Considering different kind of containers, bulk and nested:

    • Washing machine | Depyrogenation tunnel | Filling machines | Stoppering | Rod insertion and labelling for syringes | Conveyor belts | Automated inspection | Packaging line

    Case Study
    What to Consider, What are Common Problems, How to Avoid Them

    • Collision analysis
    • Basics of good glass handling
    • Technologies to avoid glass to glass contact

    Coffee Break

    Coordination Process Primary Packaging Material and Machine

    • Important parameters | Control loop | Synchronization


    Summary & End of Training Course


Markus Heinz
Markus Heinz
Florian Maurer
Florian Maurer
Karl Siemoneit
Karl Siemoneit
Folker Steden
Folker Steden

Additional Information

  • Learning Objectives

    Learning Objectives

    • Understands the nature of glass
    • Knows what glass breakage causes
    • Is aware of regulatory requirements and how to perform QC incoming inspection
    • Knows how to inspect glass containers for breakage-relevant defects
    • Is able to apply the knowledge to avoid glass breakage in the filling line
    • Is able to apply a structured way of evaluating in case of glass breakage
    • Is able to ‘read’ from the splinters and broken glass
  • Who Should Attend
    • Packaging engineers
    • Quality personnel
    • Filling line technicians
    • Supervisors and engineering support
    • Those responding to failure complaints
    • Root cause investigators

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PLEASE READ  PDA is not affiliated or contracted with any outside hotel contracting company. If someone other than PDA or the PDA chosen hotel contacts you suggesting that they represent any PDA event, they do not. It is PDA's recommendation that you book your hotel directly through the official PDA chosen hotel that is listed on our web site.

IntercityHotel Mainz

Binger Str. 21
Mainz, Germany

  • Accommodations

    Hotel Nearby

    PDA Europe recommends the reservation at the following hotel:

    IntercityHotel Mainz
    Binger Str. 21, 55131 Mainz
    Tel: +49 6131 588510

  • Amenities

How to Get Here

By Air

Nearest Airport: Frankfurt Airport - FRA Airport Phone: +49 0180 6 3724636; Distance: 32,0 km; Estimated cab fare: 45,- EUR (one way)

By Car

IntercityHotel Mainz has its own parking garage with e-charging station; Cost: 2,30 EUR/hour, 19,- EUR/day

Other Options

Mainz main station; Distance: 0,5 km


Registration Fees

Regular Price
Registration Type Price
All Participants €1.895

* For this member type or discount, online registration is not available, please contact [email protected].

Group Registration Discount: Register 3 people from the same organization as a group (at the same time) for the event and receive the 4th registration free. Other discounts cannot be applied.

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CANCELLATION: If a cancellation request is received 30 days before the event, a credit (registration fee paid minus a 200.00 USD/EUR processing fee) will be given. No credits will be given for cancellation requests received less than 30 days before the event. Cancellation requests must be emailed to [email protected].


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