This Technical Report aims to describe the underlying mechanisms and contributing factors of LER, summarize the potential clinical impact of the LER phenomenon, present guidelines for developing LER hold-time study design, and provide strategies for the mitigation of LER.

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Format: PDF (1 file 6.11 MB)

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Table of Contents:

1. Introduction
2. Glossary of Terms
3. LER Hold-Time Studies
4. Proposed Mechanisms of LER
5. Mitigation of LER
6. History and Rationale for LER Studies
7. References
8. Appendix: Case Studies of LER Occurrences

Figures and Tables Index