PDA Technical Report No. 7, (TR 7) Depyrogenation (single user digital version)
- Published
- Jan 1985
- Pages
- 124
- PDA Item Number
- 43212
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- Format
- PDF Single user
- Member Price
- $50.00
- Nonmember Price
- $100.00
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Note: This Technical Report has been retired by PDA and is no longer considered to represent current industry best practices. It is available for historical/research purposes only.
This Technical Report was prepared by PDA Depyrogenation Subcommittee.
The Depyrogenation report consists of 14 chapters, each written by an authority in the field. Each chapter describes the different methods of depyrogenating solutions and devices. Since depyrogenation is a field characterized by rapid technological advances, and due to the limitations imposed by time and space, a more comprehensive treatment of the many areas of endotoxin depyrogenation was not possible.
This report serves as a stimulus to scientists involved with the control of endotoxin and desire to increase their knowledge of the structure and function of the bacterial toxin and depyrogenation. Therefore, it documents state-of-the-art depyrogenation to the extent that the limitations stated above permitted. It is our hope that it will encourage research in all aspects of depyrogenation.
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Table of Contents
Table of Contents:
1. Endotoxin: Its Structure and Function
With Respect to Depyrogenation - Frederick C. Pearson
2. Pyrogen
Removal by Ultrafiltration - Robert S. Tutunjian
3. Application of
Reverse Osmosis in Pyrogen Removal - Lita Nelsen
4. Depyrogenation by
Distillation - Richard F. Mahoney
5. Charge-Modified Media - Martin
W. Mahard, Joseph Fiore and Richard Babineau
6. Depyrogenation by
Microporous Membrane Filters - James R. Robinson, Marguerite C. O'Dell,
Joseph Takacs, Timothy Barnes and Carole Genovesi
7. Depyrogenation by
Sintered Activated Carbon - Erich K. Reinhardt
8. Detoxification of
Endotoxin by Acid and Base - Karen Zink McCullough and Thomas J.
Novitsky
9. Depyrogenation by Hydrogen Peroxide - Marilyn J. Gould and
Thomas J. Novitsky
10. Inactivation of Endotoxin by Polymyxin B -
Thomas J. Novitsky and Marilyn J. Gould
11. Depyrogenation by Limulus
Amebocyte Lysate - Thomas J. Novitsky and Marilyn J. Gould
12.
Depyrogenation by Dry Heat - B.H. Sweet and J.F. Huxsoll
13.
Depyrogenation by Moist Heat - Thomas J. Novitsky, Sally S. Ryther and
Marilyn J. Gould
14. Inactivation of Endotoxin by Ethylene Oxide
Sterilization and Cobalt60 Irradiation - Charles T. Hudson and Robert
Nase