Skip To The Main Content
Parenteral Drug Association Connecting People, Science and Regulation ®

Development of a Freeze Drying Process

Sep 21 - Sep 22, 2017 |
Sep 22, 2017 |
Lindner Hotel City Plaza | Cologne, Germany
  • Education
  • Europe
Add event to: ICal Outlook Google Calendar

This seminar will give a thorough introduction into the Physics and Thermodynamics of Freeze-Drying. It comes with an additional overview about technical aspects to be considered and gives an overview about current technologies available on the market. It is created to introduce all people who are professionally linked to Freeze-Drying and might be of special interest for cycle developers (R&D), upscale & transfer specialists, project managers & engineers, process & site engineers, qualification & validation specialists. Open problem examination allows you to bring in a current problem linked to Freeze-Drying. The group will discuss and evaluate possible approaches for troubleshooting.

Who should attend?

This course is designed specifically for:

  • Cycle Developers (R&D)
  • Upscale & Transfer Specialists
  • Project Managers & Engineers
  • Process & Site Engineers
  • Qualification & Validation Specialists
  • Members of Parenteral Production Teams

Learning Objectives

Upon completion of this course participants will know the basic principles of all Freeze Drying aspects:
  • Physical / Thermodynamic Theory of Nucleation, Sublimation and Desorption
  • Technical & Technological Solutions to accomplish a standard process
  • Based on the prior theory, several hands-on-sessions provide practical knowledge to design a Freeze-Drying process
  • Basics of qualification of a freeze dryer

Instructor

Georg Frinke, Bayer Pharma
Georg holds a degree in Engineering from UAS, Cologne, Germany. He is Process Engineer at Bayer Pharma and responsible for the technical operation of the parenteral facility. Previously, he worked as Process Engineer for Optima (Klee) and GEA Lyophil / Steris. Among others, he is specialized in the development of customized Freeze-Drying processes (particularly upscaling with PAT) and in the qualification (FAT, SAT, IQ, OQ, PQ) of pharmaceutical freeze dryers.

 


Thursday, 21 September 2017

THEORY

9:00
Introduction

  • Introduction to Drying Technologies
  • Overview of the Freeze Drying Process
  • Properties of Water
  • Properties of Heat Transfer during Lyophilization

10:00
Nucleation

  • Scientific Basics
  • Freezing Process
  • Sensors & PAT
  • Hands-on
11:00
Coffee Break

11:30
Nucleation (Cont.)

  • Hands-on: Freezing of Sucrose in a Lyo with integrated thermo-resistant measurement
13:00
Lunch Break

14:00
Sublimation

  • Scientific Basics
  • Drying Process
  • Sensors & PAT
  • Hands-on
16:00
Coffee Break

16:30
Desorption

  • Scientific Basics
  • Residual Moisture
  • Sensors & PAT
  • Hands-on

Bring in your Questions: Real problems of Freeze Drying can be presented and will be discussed as a group

18:30
End of Day 1

Friday, 22 September 2017

TECHNOLOGIES & PRACTICE

8:30
Repetition of Previous Day Theory & Transfer of a Freeze Drying Cycle

9:00
Hands-On: Recipe Development

11:00
Coffee Break

11:30
Module Structure of a Freeze Dryer

  • Chamber & Shelf System
  • Condenser & Main Valve
  • Venting System / Filter Test
  • Refrigeration
  • Vacuum System
  • CIP / SIP Systems
12:30
Lunch Break

14:00
Module Structure of a Freeze Dryer (Cont.)

  • System Benchmarks
  • Performance Criteria
  • Installation vs. Process
  • Design Criteria & Engineering Aspects
15:00
Coffee Break

15:30
Hands-on:

  • Evaluation of the Lyo experiment & samples of collapsed probe
16:30
Qualification Validation Hints for the SAT
17:00
End of Training Course

4 Ways to register

Please remember to log in if you are a member of PDA already! 

If you come from a Governmental or Health Authority Institution or from an Academic Organization please contact Ms. Antje Petzholdt before registering. She will verify your status and register you.

  • All registrations which will involve visa matters will have to be submitted to PDA EU four weeks prior to the start of the event at the latest. For later registrations, PDA Europe will be unable to assist participants in any visa affairs.
  • All costs incurring in connection with visa affairs shall be borne by registrants. (This applies in particular to costs for submitting documents by courier.)
  • Potential participants must be clients of UPS shipping agency and submit their UPS customer reference number to PDA EU (together with their registration).
  • No PDA membership obtainable upon booking training course, workshop or other related event.

Registration Fees

Are you entiteld to receive a discount? Need Help?

All Participants

1,495 Euro

All fees given in Euro and excluding VAT (7%)

Contact

Antje PetzholdtAntje Petzholdt
Manager Registration, Chapters & Membership
Tel: +49 (0) 30 43 655 08-10
Fax: +49 (0) 30 43 655 08-66
Email

Exterior

Lindner Hotel City Plaza
Magnusstrasse 20
50672 Cologne
Tel: +49 221 2034-700
Fax: + 49 221 2034-777
Email
Hotel Website

Located at the trendy Friesenplatz, Lindner Hotel City Plaza welcomes its guests in style with modern, sophisticated and charming elegance. You are right in the middle of the media metropolis of Cologne and can experience everything it has to offer with a welcoming touch of luxury.

The elegant rooms each have a satellite TV, a seating area, and an en-suite bathroom with complimentary toiletries. WiFi is free throughout.

PDA Europe has reserved a limited number of rooms until the 3rdJuly 2017

Book your room for the PDA Group Rate by phone.
Single Room € 129 per night*
Double Room € 159 per night*

*Rates include the following services and benefits free of charge:

  • Buffet Breakfast in the restaurant
  • Wireless Internet Connection (Wi-Fi)
  • Taxes and Service will apply

How to Get There

  • Subway (0.1 km) Station: Friesenplatz – Lines: 3,4,5,12,15
  • City train (1.0 km) Station: Hansaring – Lines: S 6, S 11, S 12
  • Tram (0.1 km) Station: Friesenplatz – Lines: 3,4,5,12,15
  • Bus (0.6 km) Station: Rudolfplatz – Lines: 136, 146
  • Metro station 120 m away

Parking

€ 25,00 per day

Photos

Sponsorship and Exhibit Opportunities are Available!

For more information about exhibit and sponsorship opportunities, please contact:

Nadjeschda Gomez-Stahl
Manager Exhibition & Sponsorship
Tel: +49 (0) 30 43 655 08-23
Fax: +49 (0) 30 43 655 08-66
Email

Closed
https://www.pda.org/docs/default-source/website-document-library/eu-conferences/2017/9_freeze-drying/registration-form.pdf

Downloads

Directions