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Best Practices for Glass Primary Containers

Oct 06 - Oct 07, 2020
Mainz, Germany

This two-day course will offer insights into the science of glass and its inherent properties. It will review container design and dimensioning, cover glass strength and fracture mechanics as well as review the fundamental principles of good glass handling and inspection.

  • Education
  • Europe

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Program Highlights
This course will include a Site Visit at the SCHOTT facilities on the 06 October 2020!


Glass vials, ampoules, syringes and cartridges are commonly used in packaging of parenteral pharmaceuticals. Good glass handling practices are essential to assuring glass-based container performance as intended in maintaining the safety and efficacy of the drug product.

The two-day course will offer insights into the science of glass and its inherent properties. It will review container design and dimensioning, cover glass strength and fracture mechanics as well as review the fundamental principles of good glass handling and inspection. The course will follow step-by-step the processes for packaging of parenterals in vials, ampoules, cartridges and syringes. Further insights into glass breakage including an overview of fracture analysis using fractography will be presented.


  • Technical aptitude
  • Some familiarity with pharmaceutical fill/finish processes


  • Day 1
  • Day 2
  • Tuesday, 06 October 2020

    Welcome and Introduction Participants' Expectations

    Manufacture and Characteristics of Glass as Primary Packaging Material

    Glass Science

    • Chemical structure
    • Physical properties
    • Different glass types in the pharmaceutical industry

    Coffee Break

    Glass Making

    • Glass Melting
    • Tubing Production
    • Container conversion
    • Molded containers

    Lunch Break

    Glass Strength and Fracture Mechanics

    • Trigger for glass breakage
    • Crack formation and propagation
    • Theory of Fractography

    Site Visit SCHOTT Tubular Glass Manufacturing

    Coffee Break

    Receiving Inspection of Glass Primary Packaging Material

    Requirements from Pharmacopoeias (EP, JP, USP) and Incoming Inspection

    • Overview Pharmacopoeia
    • Testing Parameters
    • Testing Methods, Equipment, Tools
    • Defects and PDA Technical Report #43

    How to Do in Practice

    • Sampling (AQL)
    • Sample size
    • Testing
    • Documentation
    • Supplier certification & test reduction

    End of Day 1
  • Wednesday, 07 October 2020

    Recap of Learning Objectives Day 1

    Receiving Inspection of Glass Primary Packaging Material (cont.)

    What to Consider, What are the Common Problems, How to Avoid Them

    • Indications for (later) glass breakage | Practical examples

    Coffee Break

    Coordination Process Packaging Manufacturer and Customer

    • Important parameters | Measured variables | Regulating variables | Control loop |Interaction with manufacturer | Effort reduction

    Machine Use of Glass Primary Packaging Material

    Machine Runability of Glass Primary Packaging Material

    • Roughness of glass primary packaging material | Geometrics, tolerances | Quality of glass | Impact of machine speed

    Lunch Break

    Use of Glass Primary Packaging Material Along the Process Chain Considering different kind of containers, bulk and nested:

    • Washing machine | Depyrogenation tunnel | Filling machines | Stoppering | Rod insertion and labelling for syringes | Conveyor belts | Automated inspection | Packaging line

    Case Study
    What to Consider, What are Common Problems, How to Avoid Them

    • Collision analysis
    • Basics of good glass handling
    • Technologies to avoid glass to glass contact

    Coffee Break

    Coordination Process Primary Packaging Material and Machine

    • Important parameters | Control loop | Synchronization

    Q & A

    Summary & End of Training Course


Felix Brosi
Felix Brosi
Florian Maurer
Florian Maurer
Karl Siemoneit
Karl Siemoneit
Klaus Ullherr
Klaus Ullherr
Syntegon Technology (former Bosch Packaging Technology)

Additional Information

  • Learning Objectives

    Learning Objectives

    • Understands the nature of glass
    • Knows what glass breakage causes
    • Is aware of regulatory requirements and how to perform QC incoming inspection
    • Knows how to inspect glass containers for breakage-relevant defects
    • Is able to apply the knowledge to avoid glass breakage in the filling line
    • Is able to apply a structured way of evaluating in case of glass breakage
    • Is able to ‘read’ from the splinters and broken glass
  • Who Should Attend

    Who Should Attend

    • Packaging engineers
    • Quality personnel
    • Filling line technicians
    • Supervisors and engineering support
    • Those responding to failure complaints
    • Root cause investigators

Got a Question? We have answers

Contact Us


PLEASE READ  PDA is not affiliated or contracted with any outside hotel contracting company. If someone other than PDA or the PDA chosen hotel contacts you suggesting that they represent any PDA event, they do not. It is PDA's recommendation that you book your hotel directly through the official PDA chosen hotel that is listed on our web site.

Novotel Mainz

Augustusstraße 6
Mainz, Germany
Phone: +49 6131 9540

Novotel Mainz
  • Accommodations
    PDA Europe recommends the reservation at the following hotel.

    The general terms of business are valid at the event hotels.

    Novotel Mainz
    Augustusstraße 6
    55131 Mainz
    Tel.: +49 6131 9540
    Fax: +49 6131954100
    Hotel Website

    Price per Room/Night: 127,00 Euro per room, per night, Wi-Fi and Buffet Breakfast included, Direct Payment in Hotel

  • Amenities

How to Get Here

By Air

Nearest Airport: Frankfurt Airport - FRA
Airport Phone: +49 0180 6 3724636

By Car

38 min, 38 km by car. The Novotel Mainz is located at Augustusstraße 6.

Other Options

More information coming soon.


Registration Fees

Regular Price
Registration Type Price
All Participants €1.595

All fees given in Euro and excluding VAT

* For Government/Health Authority/Academic nonmembers, online registration is not available and must be faxed in.

All rates in US dollars. To receive the prevailing rate, PDA must receive your registration(s) by 5:00 p.m. ET on or before the date noted.

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REFUND: If a refund request is sent 30 days before the event, a full refund will be given minus a $200 fee. After this period, no refunds will be given. Refund requests must either be faxed to + (301) 986-1093 or emailed to [email protected]. Phone messages are not accepted.


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